Hyperbaric IV Ozone & Oxygen Therapy 10-Pass Therapy

10-Pass Hyperbaric IV Ozone Therapy is the most intensive form of medical ozone therapy available. At Upper Room Clinic we offer this advanced protocol in a closed sterile circuit — for patients seeking deep oxygenation and immune support.

What is it?

In a single 10-Pass session, your blood is drawn, exposed to a measured dose of ozone-oxygen gas at increased pressure, and returned to your body — repeated 10 times in one visit. Each “pass” delivers concentrated, medical-grade ozone directly to the bloodstream, supporting cellular oxygenation, mitochondrial function, and immune signalling.

This contrasts with traditional IV ozone (single pass) and major autohemotherapy (MAH) — 10-Pass is significantly more intensive and deeper in effect.

The closed sterile circuit

Our 10-Pass equipment uses a fully closed, sterile, single-use circuit. Your blood never contacts air or contaminants — it's drawn, treated, and returned in a single uninterrupted process under medical supervision. This is one of the safest forms of ozone therapy available.

The Benefits

We use 10-Pass Ozone Therapy as part of integrative care plans for:

Chronic infections — viral, bacterial, fungal, including chronic Lyme support
Mitochondrial dysfunction and chronic fatigue
Autoimmune conditions — as an immunomodulator
Pre- and post-surgical recovery support
Integrative cancer care — adjunctive to conventional treatments, with oncologist coordination
Performance and longevity — for patients optimizing healthspan

Who's a Candidate?

10-Pass is contraindicated in patients with G6PD deficiency, hyperthyroidism, certain bleeding disorders, and during pregnancy. We screen for these at intake and require an initial consultation before starting a 10-Pass course.

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What to expect & how often

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During Treatment

A 10-Pass session takes 60–90 minutes. You'll be in a comfortable reclining chair throughout. Most patients feel energized after the session, though some report mild flu-like symptoms 24–48 hours after as the body responds. We monitor you throughout, and your physician adjusts the protocol session-by-session. Initial protocols typically include 5–10 sessions over 2–4 weeks, with maintenance frequencies depending on the condition. Your treatment plan is built during the initial consultation.

Why Choose Upper Room Clinic for 10-Pass Ozone

10-Pass Ozone Therapy is one of the more advanced ozone protocols offered in Canada — and the equipment, technique, and screening matter as much as the therapy itself. At Upper Room Clinic in Toronto:

Closed sterile circuit — your blood never contacts air or contaminants throughout the 10 passes
Physician supervision — Dr. Kostovic brings 35+ years in integrative oncology, regenerative medicine, and chronic-illness care
Pre-treatment screening — G6PD, thyroid, coagulation, and pregnancy status reviewed before every patient starts a 10-Pass course
Patient-centred protocols — dose, frequency, and adjunctive supports adapted session-by-session based on your response
Whole-person medicine — 10-Pass ozone is integrated into broader plans alongside IV nutrients, RGCC therapies, and PRP where appropriate
Convenient Toronto location at 1849 Yonge Street, with Oakville coming soon, serving the GTA

Patients choose us for the combination of medical rigour and individualized, evidence-based care.